- Hi, Jeff...
- Two years ago, in 2000, you published this artilcle I
sent you:
- http://www.rense.com/general3/proges.htm
- Later in the year, a study on altered leukocyte gene
expression in parturient dairy cows received a 2nd place award for research
among graduate students which noted the effects of progesterone on leukocytes.
- See the link here: <LINK>
-
- Since you published my report in 2000, the following
29 studies relative to progesterone receptors and cancer have been published:
-
- 1: Chearskul S, Bhothisuwan K, Churintrapun M, Semprasert
N, Onreabroi S.
- Estrogen receptor-alpha mRNA in primary breast cancer:
relationship to estrogen
- and progesterone receptor proteins and other prognostic
factors.
- Asian Pac J Allergy Immunol. 2002 Mar;20(1):13-21.
- PMID: 12125913 [PubMed - in process]
-
- 2: Press M, Spaulding B, Groshen S, Kaminsky D, Hagerty
M, Sherman L,
- Christensen K, Edwards DP.
- Comparison of different antibodies for detection of progesterone
receptor in
- breast cancer.
- Steroids. 2002 Aug;67(9):799-813.
- PMID: 12123792 [PubMed - in process]
-
- 3: Costa SD, Lange S, Klinga K, Merkle E, Kaufmann M.
- Factors influencing the prognostic role of oestrogen
and progesterone receptor
- levels in breast cancer-results of the analysis of 670
patients with 11 years of
- follow-up.
- Eur J Cancer. 2002 Jul;38(10):1329-34.
- PMID: 12091062 [PubMed - in process]
-
- 4: Fabjani G, Tong D, Czerwenka K, Schuster E, Speiser
P, Leodolter S,
- Zeillinger R.
- Human progesterone receptor gene polymorphism PROGINS
and risk for breast cancer
- in Austrian women.
- Breast Cancer Res Treat. 2002 Mar;72(2):131-7.
- PMID: 12038703 [PubMed - in process]
-
- 5: Jacobsen BM, Richer JK, Schittone SA, Horwitz KB.
- New Human Breast Cancer Cells to Study Progesterone Receptor
Isoform Ratio
- Effects and Ligand-independent Gene Regulation.
- J Biol Chem. 2002 Aug 2;277(31):27793-800.
- PMID: 12021276 [PubMed - in process]
-
- 6: Spurdle AB, Hopper JL, Chen X, McCredie MR, Giles
GG, Venter DJ, Southey MC,
- Chenevix-Trench G.
- The progesterone receptor exon 4 Val660Leu G/T polymorphism
and risk of breast
- cancer in Australian women.
- Cancer Epidemiol Biomarkers Prev. 2002 May;11(5):439-43.
- PMID: 12010857 [PubMed - indexed for MEDLINE]
-
- 7: Lakhani SR, Van De Vijver MJ, Jacquemier J, Anderson
TJ, Osin PP, McGuffog
- L, Easton DF.
- The pathology of familial breast cancer: predictive value
of immunohistochemical
- markers estrogen receptor, progesterone receptor, HER-2,
and p53 in patients
- with mutations in BRCA1 and BRCA2.
- J Clin Oncol. 2002 May 1;20(9):2310-8.
- PMID: 11981002 [PubMed - indexed for MEDLINE]
-
- 8: Vienonen A, Syvala H, Miettinen S, Tuohimaa P, Ylikomi
T.
- Expression of progesterone receptor isoforms A and B
is differentially regulated
- by estrogen in different breast cancer cell lines.
- J Steroid Biochem Mol Biol. 2002 Mar;80(3):307-13.
- PMID: 11948015 [PubMed - indexed for MEDLINE]
-
- 9: Brankovic-Magic M, Jankovic R, Neskovic-Konstantinovic
Z,
- Nikolic-Vukosavljevic D.
- Progesterone receptor status of breast cancer metastases.
- J Cancer Res Clin Oncol. 2002 Jan;128(1):55-60.
- PMID: 11862473 [PubMed - indexed for MEDLINE]
-
- 10: Richer JK, Jacobsen BM, Manning NG, Abel MG, Wolf
DM, Horwitz KB.
- Differential gene regulation by the two progesterone
receptor isoforms in human
- breast cancer cells.
- J Biol Chem. 2002 Feb 15;277(7):5209-18.
- PMID: 11717311 [PubMed - indexed for MEDLINE]
-
- 11: Runnebaum IB, Wang-Gohrke S, Vesprini D, Kreienberg
R, Lynch H, Moslehi R,
- Ghadirian P, Weber B, Godwin AK, Risch H, Garber J, Lerman
C, Olopade OI,
- Foulkes WD, Karlan B, Warner E, Rosen B, Rebbeck T, Tonin
P, Dube MP, Kieback
- DG, Narod SA.
- Progesterone receptor variant increases ovarian cancer
risk in BRCA1 and BRCA2
- mutation carriers who were never exposed to oral contraceptives.
- Pharmacogenetics. 2001 Oct;11(7):635-8.
- PMID: 11668223 [PubMed - indexed for MEDLINE]
-
- 12: Lin VC, Eng AS, Hen NE, Ng EH, Chowdhury SH.
- Effect of progesterone on the invasive properties and
tumor growth of
- progesterone receptor-transfected breast cancer cells
MDA-MB-231.
- Clin Cancer Res. 2001 Sep;7(9):2880-6.
- PMID: 11555606 [PubMed - indexed for MEDLINE]
-
- 13: Bonkhoff H, Fixemer T, Hunsicker I, Remberger K.
- Progesterone receptor expression in human prostate cancer:
correlation with
- tumor progression.
- Prostate. 2001 Sep 15;48(4):285-91.
- PMID: 11536308 [PubMed - indexed for MEDLINE]
-
- 14: Chu KC, Anderson WF, Fritz A, Ries LA, Brawley OW.
- Frequency distributions of breast cancer characteristics
classified by estrogen
- receptor and progesterone receptor status for eight racial/ethnic
groups.
- Cancer. 2001 Jul 1;92(1):37-45.
- PMID: 11443607 [PubMed - indexed for MEDLINE]
-
- 15: Vyzula R, Zaloudik J, Dusek L, Vermousek I.
- Seasonal variation in estrogen and progesterone receptor
levels in breast
- cancer--a factor in data interpretation.
- Neoplasma. 2001;48(1):19-25.
- PMID: 11327533 [PubMed - indexed for MEDLINE]
-
- 16: Spurdle AB, Webb PM, Purdie DM, Chen X, Green A,
Chenevix-Trench G.
- No significant association between progesterone receptor
exon 4 Val660Leu G/T
- polymorphism and risk of ovarian cancer.
- Carcinogenesis. 2001 May;22(5):717-21.
- PMID: 11323389 [PubMed - indexed for MEDLINE]
-
- 17: Yoo K, Tajima K, Park S, Kang D, Kim S, Hirose K,
Takeuchi T, Miura S.
- Postmenopausal obesity as a breast cancer risk factor
according to estrogen and
- progesterone receptor status (Japan).
- Cancer Lett. 2001 Jun 10;167(1):57-63.
- PMID: 11323099 [PubMed - indexed for MEDLINE]
-
- 18: Latil A, Bieche I, Vidaud D, Lidereau R, Berthon
P, Cussenot O, Vidaud M.
- Evaluation of androgen, estrogen (ER alpha and ER beta),
and progesterone
- receptor expression in human prostate cancer by real-time
quantitative reverse
- transcription-polymerase chain reaction assays.
- Cancer Res. 2001 Mar 1;61(5):1919-26.
- PMID: 11280747 [PubMed - indexed for MEDLINE]
-
- 19: Lohmann C, Gibney E, Cotsonis G, Lawson D, Cohen
C.
- Progesterone receptor immunohistochemical quantitation
compared with cytosolic
- assay: correlation with prognosis in breast cancer.
- Appl Immunohistochem Mol Morphol. 2001 Mar;9(1):49-53.
- PMID: 11277415 [PubMed - indexed for MEDLINE]
-
- 20: Sasaki M, Dharia A, Oh BR, Tanaka Y, Fujimoto S,
Dahiya R.
- Progesterone receptor B gene inactivation and CpG hypermethylation
in human
- uterine endometrial cancer.
- Cancer Res. 2001 Jan 1;61(1):97-102.
- PMID: 11196205 [PubMed - indexed for MEDLINE]
-
- 21: Bamberger AM, Milde-Langosch K, Schulte HM, Loning
T.
- Progesterone receptor isoforms, PR-B and PR-A, in breast
cancer: correlations
- with clinicopathologic tumor parameters and expression
of AP-1 factors.
- Horm Res. 2000;54(1):32-7.
- PMID: 11182633 [PubMed - indexed for MEDLINE]
-
- 22: Fazzari A, Catalano MG, Comba A, Becchis M, Raineri
M, Frairia R, Fortunati
- N.
- The control of progesterone receptor expression in MCF-7
breast cancer cells:
- effects of estradiol and sex hormone-binding globulin
(SHBG).
- Mol Cell Endocrinol. 2001 Feb 14;172(1-2):31-6.
- PMID: 11165037 [PubMed - indexed for MEDLINE]
-
- 23: Elledge RM, Green S, Pugh R, Allred DC, Clark GM,
Hill J, Ravdin P, Martino
- S, Osborne CK.
- Estrogen receptor (ER) and progesterone receptor (PgR),
by ligand-binding assay
- compared with ER, PgR and pS2, by immuno-histochemistry
in predicting response
- to tamoxifen in metastatic breast cancer: a Southwest
Oncology Group Study.
- Int J Cancer. 2000 Mar 20;89(2):111-7.
- PMID: 10754487 [PubMed - indexed for MEDLINE]
-
- 24: Huang WY, Newman B, Millikan RC, Schell MJ, Hulka
BS, Moorman PG.
- Hormone-related factors and risk of breast cancer in
relation to estrogen
- receptor and progesterone receptor status.
- Am J Epidemiol. 2000 Apr 1;151(7):703-14.
- PMID: 10752798 [PubMed - indexed for MEDLINE]
-
- 25: Klijn JG, Setyono-Han B, Foekens JA.
- Progesterone antagonists and progesterone receptor modulators
in the treatment
- of breast cancer.
- Steroids. 2000 Oct-Nov;65(10-11):825-30. Review.
- PMID: 11108894 [PubMed - indexed for MEDLINE]
-
- 26: Desreux J, Kebers F, Noel A, Francart D, Van Cauwenberge
H, Heinen V,
- Thomas JL, Bernard AM, Paris J, Delansorne R, Foidart
JM.
- Progesterone receptor activation. an alternative to SERMs
in breast cancer.
- Eur J Cancer. 2000 Sep;36 Suppl 4:S90-1.
- PMID: 11056336 [PubMed - indexed for MEDLINE]
-
- 27: Shen KL, Yang LS, Hsieh HF, Chen CJ, Yu JC, Tsai
NM, Harn HJ.
- Microsatellite alterations on human chromosome 11 in
in situ and invasive breast
- cancer: a microdissection microsatellite analysis and
correlation with p53, ER
- (estrogen receptor), and PR (progesterone receptor) protein
immunoreactivity.
- J Surg Oncol. 2000 Jun;74(2):100-7.
- PMID: 10914818 [PubMed - indexed for MEDLINE]
-
- 28: Wang-Gohrke S, Chang-Claude J, Becher H, Kieback
DG, Runnebaum IB.
- Progesterone receptor gene polymorphism is associated
with decreased risk for
- breast cancer by age 50.
- Cancer Res. 2000 May 1;60(9):2348-50.
- PMID: 10811106 [PubMed - indexed for MEDLINE]
-
- 29: Lin VC, Ng EH, Aw SE, Tan MG, Ng EH, Bay BH.
- Progesterone induces focal adhesion in breast cancer
cells MDA-MB-231
- transfected with progesterone receptor complementary
DNA.
- Mol Endocrinol. 2000 Mar;14(3):348-58.
- PMID: 10707953 [PubMed - indexed for MEDLINE]
-
- It would seem there is interest in progesterone receptors
relative to cancer. There is continued interest in mouse mammary tumor
virus and its relationship to HIV/AIDS.
-
- To keep you in the forefront of the news in this area,
you should be aware that recent research has shown a close relationship
between a retrovirus found associated with multiple sclerosis and another
retrovirus found associated with schizophrenia. It is also the case that
these two retroviruses show relationship to "human endogenous virus
type W" as well as to baboon endogenous virus, Mason-Pfizer monkey
virus, Woolly Monkey Sarcoma Virus, Gibbon Ape Leukemia Virus, and several
mouse leukemia retroviruses including the mouse mammary tumor viruses.
-
- It would appear, in examination of the literature relative
to these viruses, and, particularly, to the schizophrenia-associated retrovirus,
that they are more likely to infect persons with an HLA-DR tissue type
than those that don't. It appears that prolactin is the hormone here instead
of progesterone. It appears that non-whites are more likely to have HLA-DR
tissue type than whites.
- I note in the literature that the first isolation of
a "virus-like body" associated with
- schizophrenia occurred in 1957 in Russia. See this reference:
- [Virus-like bodies in the cerebrospinal fluid in schizophrenia.]
- MAR GI, SVIADATS AM.
- Zh. nevropat. psikhiat., Moskva 1957;57(9):1098-100. Russian.
- >From OLDMEDLINE
- Why was it not until 2001 that there was evidence of
a schizophrenia-associated retrovirus
- presented in the literature? See these references:
- <LINK>Karlsson
H, Bachmann S, Schroder J, McArthur J, Torrey EF, Yolken RH.
- Retroviral RNA identified in the cerebrospinal fluids
and brains of individuals with schizophrenia.
- Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4634-9.
- PMID: 11296294 [PubMed - indexed for MEDLINE]
-
- <LINK>Lewis
DA.
- Retroviruses and the pathogenesis of schizophrenia.
- Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4293-4. No
abstract available.
- PMID: 11296280 [PubMed - indexed for MEDLINE]
-
- Note, Jeff, that this "schizophrenia-associated
retrovirus" is very similar to baboon endogenous retrovirus, Mason-Pfizer
monkey virus, Gibbon Ape
- Leukemia Virus, and several of the immunodeficiency-causing
Simian Retroviruses that were under study by the Special Virus Cancer Program
in
- the United States between 1962 and 1978. Note that in
1972, the United States met with and studied the Russian schizophrenia
research. See
- here:
- The 1972 NIMH mission to assess schizophrenic research
in the U.S.S.R.
- Brown BS, Kopin IJ, Kramer M, Mosher LR, Pollin
WN, Salmoiraghi GC, Torrey EF.
- Schizophr Bull. 1974;(9):148-153. No Abstract
Available.
- PMID: 4377469 [PubMed - indexed for MEDLINE]
- From PubMed
- Interestingly, again, this schizophrenia-associated retrovirus,
reported in 2001, above, shows simiarity to baboon
endogenous retrovirus, Mason-Pfizer monkey virus, Gibbon Ape leukemia virus,
and to the others I have mentioned. HL-23V, the first
"human retrovirus" discovered in the 1970s and associated with
human leukemia is also closely related to these agents.
Here are some early sources on HL-23V: Isolation of
a virus closely related to gibbon ape leukaemia virus from cells infected
with virus (HL-23V) released by human leukaemic cells.
-
-
- Bergholz CM, Wolfe LG, Schulz GA, Deinhardt
F, Miller NR, Reitz MS.
- J Gen Virol. 1980 May;48(1):111-121.
- PMID: 6247431 [PubMed - indexed for MEDLINE]
- >From PubMed
- Homology between HL-23V and primate viruses and search
for proviral DNA sequences of simian sarcoma associated virus and baboon
endogenous virus in DNA from human leukemic cells.
- Mishra L, Hong D, Baluda MA.
- Leuk Res. 1979;3(5):285-296. No Abstract Available.
- PMID: 230394 [PubMed - indexed for MEDLINE]
- From PubMed
- Oncogenicity of the C-type virus HL-23V in marmosets
and characterization of virus isolated from an HL-23V-induced marmoset
tumor: comparison with simian sarcoma virus type 1.
- Bergholz CM, Wolfe LG, Deinhardt F.
- Primates Med. 1978;10:135-141.
- PMID: 205850 [PubMed - indexed for MEDLINE]
- From PubMed
- Oncogenicity in marmosets of HL-23V, a type C oncornavirus
isolated from human leukemic cells, and comparison with simian sarcoma
virus type 1 (SSV-1/SSAV-1).
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