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Doctor's 32% Error Rate
'Not Unusual' Says Inquiry
By Jeremy Laurance
Health Editor
The Independent - UK
2-5-3

A consultant paediatrician who mistakenly diagnosed almost one third of his patients as having epilepsy had an error rate that was "not unusual", an inquiry has concluded.
 
The high error rate, revealed by a review of almost 2,000 children diagnosed with epilepsy at Leicester Royal Infirmary over an 11-year period, could be similar at other hospitals, the author of the inquiry said yesterday.
 
Between 1990 and 2001, Dr Andrew Holton, a consultant paediatrician at the Royal Infirmary, diagnosed 1,948 children with epilepsy of whom 618 (32 per cent) had their diagnoses changed or recategorised as a result of the inquiry, the report said. All the misdiagnosed children were over-treated or given the wrong treatment and many suffered side-effects from powerful cocktails of drugs. The families of 308 children are suing the University Hospitals NHS Trust, which runs the infirmary, for compensation.
 
Richard Newton, the president of the British Paediatric Neurology Association who led the inquiry, said: "I always worry this might be repeated elsewhere. There is the potential for that."
 
Epilepsy affects one in 200 children but is difficult to diagnose because children can suffer fits for many reasons, including fainting, migraine and fever, not related to epilepsy. In most hospitals, cases are diagnosed by a general paediatrician, but specialist expertise in paediatric neurology is necessary to make an accurate diagnosis.
 
Only two known studies have been conducted of epilepsy diagnosed by general paediatricians, one in Copenhagen which found a 39 per cent error rate and one in Sarajevo where the error rate was 38 per cent.
 
Dr Newton said Britain faced a severe shortage of paediatric neurologists. "Over the last 30 years there have been about 50 reviews of epilepsy whose findings have been published, filed and forgotten. I am anxious that shouldn't happen again," Dr Newton said. The inquiry report, published yesterday, confirmed the findings of an interim investigation in November 2001, which found Dr Holton had diagnosed epilepsy in children who had suffered any kind of recurrent episode including behavioural outbursts, headaches or abnormal movements. He frequently ignored "normal" EEG reports (measuring electrical activity in the brain) and prescribed excessive doses of drugs.
 
The parents of Annabelle Appleyard, six, from Market Harborough, said her condition had dramatically improved since she came off drugs prescribed by Dr Holton. Her mother, Rosalind, said: "We like her better now she is not on medication.She is far more lively and has got more personality. I am not saying it is easier but it is more of the child we like to see."
 
A separate review of Dr Holton's behaviour towards parents found he had adopted the "wrong approach", in some cases misleading them, or causing unnecessary anxiety.
 
Peter Reading, chief executive of Leicester Royal Infirmary, said Dr Holton, who has been suspended since May 2001, would face a disciplinary tribunal. However, because he had been working alone with inadequate resources and a high case load, he would not be sacked. The trust is supporting his request to retrain in another specialty outside Leicester.
 
http://news.independent.co.uk/uk/health/story.jsp?story=375685



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