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Death Toll Rises As Multi
Mystery Illnesses Plague India

From Patricia Doyle, PhD
dr_p_doyle@hotmail.com
7-12-3

Hello Jeff - The illness in West Bengal that is killing children is thought to be Influenza B. I am wondering how Influenza B would cause some of the symptoms described including salivation and stiffening of the jaw. Some symptoms, however, did sound reminiscent of Madagascar Mystery Illness. Only children are victims of this disease which is also curious to me. Influenza B would surely affect the total population, especially elderly.
 
I must admit that Influenza B does sound more legitimate then the cause that the Indian government claimed. The government claimed that the illness causing children's deaths was caused by bad weather.
 
Also the death toll in Andhra Pradesh continues to rise from a disease that was originally thought to be a form of Japanese Encephalitis. Both adults and children have succumbed to the illness.
 
Patricia Doyle
 
A ProMed Mail Post
 
[1] Date: Fri, 11 Jul 2003 Source: Sify.com [edited] http://sify.com/news/scienceandmedicine/fullstory.php?id=13195608&vsv=94
 
4 more deaths and 6 fresh cases of mysterious fever have been reported, taking the casualty toll in the current spread of suspected encephalitis to 84 in 6 districts of Andhra Pradesh. Unofficial sources had put the death toll at 103, but the Health Services Director said that the latest figure was 84, including 4 more deaths in the last 24 hours. A child in Warangal and 3 children in adjoining Karimnagar district died, while 6 fresh cases -- 3 from each of the 2 districts -- were reported, taking the number of cases to 157. The official gave the breakdown as Warangal 66, Karimnagar 58, Nizamabad 11, Adilabad 9, Krishna 11, and Nellore 2.
 
As anti-vector measures, the authorities conducted anti-larval operations in 171 villages of Karimnagar and 33 villages in Warangal. Besides, fogging was done in 37 villages of Karimnagar and 23 of Warangal. Pyrethrum was sprayed in 37 villages of Karimnagar and 23 of Warangal, while malathion spraying was conducted in 12 villages of Karimnagar and 10 of Warangal. As part of the preventive and control measures taken, chlorination of drinking water sources was regularly checked on residual chlorine. Altogether 84 medical and paramedical teams have been deployed to conduct surveillance and for treatment, the Director said in a statement.
 
However, as more casualties were reported, the Government constituted a 5-member committee of experts to conduct a detailed analysis and suggest remedial measures to stop the spate of viral fever deaths in the State. At a review meeting on the precautionary measures, Chief Minister N Chandrababu Naidu said anti-mosquito operations should be taken up in the State for the next 3 months on a war-footing. In a press release later, he said a detailed calender should be formulated to raise awareness and take up cleaning operations like road sweeping, keeping the premises clean and tidy, chlorinating drinking water, and intensifying the anti-larvae operations. Audio and video cassettes, pamphlets, and posters should be brought out to spread awareness. The Chief Minister will be holding a 150-minute discussion with officials and the public to take up preventive measures to curtail the spread of diseases especially, SVE [suspected viral encephalitis -- see newswire below - Mod.MPP], GE [? JE - Japanese encephalitis] and dengue in the State. The programme would be telecast live on Ku Band, Doordarshan Saptagiri (DD-8) and In-Cable.
 
-- ProMED-mail <promed@promedmail.org>
 
******
[2] Date: 11 Jul 2003
From: ProMED-mail <promed@promedmail.org>
Source: Hindustani Times 10 Jan 2003 [edited] http://www.hindustantimes.com/news/181_303870,0008.htm
 
Andhra Viral Fever Toll Mounts To 87 State Machinery On High Alert
 
With 10 more deaths of children due to viral fever in 3 districts of Andhra Pradesh, the toll has mounted to 87, even as the state machinery has been put on high alert to check its spread.
 
During the last 24 hours, 5 deaths were reported from Warangal, 4 in Karimnagar, and one in Ranga Reddy district, official sources said.
 
Expressing concern over the alarming rise in death rate among children due to the viral fever, Chief Minister N Chandrababu Naidu announced setting up of a 5-member expert committee to conduct an analysis of the suspected viral encephalitis (SVE), they said.
 
The expert committee is expected to submit its report in a couple of days, they said.
 
Naidu, who earlier had announced an ex-gratia payment of Rs 50,000 [USD 1084] for each of the family of the deceased, exempted medical and health staff from taking part in the ongoing janmabhoomi community development programme. He asked them to be on high alert in Telangana districts of Adilabad, Karimnagar, Warangal, Nalgonda and Nizamabad districts.
 
Niloufer hospital superintendent Dr Nck Reddy said 3 children who were brought in a bad condition on Wednesday, died within an hour, and about 10 children with similar symptoms were undergoing treatment.
 
Medical teams from National Institute of Communicable Diseases, Delhi, and National Institute of Virology, Pune, have collected the blood samples to identify the virus and the reports are awaited, official sources said.
 
The state would set up a research and analysis cell to conduct a detailed investigation into the SVE outbreaks reported in certain pockets of the state in 2002 to carry out a comparative study, according to an official release.
 
The cell would submit its report soon besides advising the health department on the measures to be taken to contain SVE and other undiagnosed outbreaks, it said.
 
-- ProMED-mail <promed@promedmail.org>
 
[In the last ProMED-mail posting on this outbreak (see Unexplained deaths - India (Andhra Pradesh) (02) 20030709.1679), there was a suggestion that preliminary testing at the "New Delhi-based National Institute Communicable Diseases and Pune's National Institute of Virology" had identified Japanese encephalitis as the etiology of this outbreak. The above newswire further supports this, as there are vector control activities underway, presumably aimed at interrupting the vector-borne transmission of Japanese encephalitis (see comments on earlier referenced ProMED-mail article for listing of known vectors in India). It should be noted that all of the information posted thus far on ProMED-mail related to this outbreak comes from newswire reports and not from official reports from either the Andhra Pradesh Department of Health or the National Ministry of Health. More information on this outbreak and investigation from official sources would be appreciated. - Mod.MPP]
 
 
UNDIAGNOSED DEATHS, CHILDREN - INDIA (WEST BENGAL) (07)
 
************** A ProMED-mail post
<http://www.promedmail.org>
ProMED-mail is a program of the International Society for Infectious Diseases <http://www.isid.org>
 
Date: 11 Jul 2003 From: ProMED-mail <promed@promedmail.org>
Source: WHO India website (11-15 June 2003) [accessed 11 Jul 2003] <http://www.whoindia.org/Happenings/Outbreak/feveroutbreakWB.htm>
 
 
A Preliminary Report of an investigation of a Fever Cases in Murshidabad District, West Bengal ------------------ Cases of fever with respiratory symptoms were reported in the district during the months of May and June 2003. The Rapid Response Team of the district, a team from National Institute of Enteric Diseases, Kolkatta National Institute of Virology, Pune, along with the National Institute of Communicable Diseases investigated the episode. A total of 719 cases and 45 deaths were reported during the period 15 May - 14 Jun 2003. 80 percent of the deaths were reported in children under 10 years of age. The laboratory investigation carried out showed the possibility of influenza B virus infection as the cause of this episode. The virus isolation results are awaited.
 
Summary
 
In response to a news item, a team from National Institute of Communicable Diseases investigated the fever cases in Murshidabad district of West Bengal during 11-15 Jun 2003.
 
A total of 719 cases and 45 deaths have been reported during the period from 15 May to 14 Jun 2003.
 
Maximum numbers of (82.2 percent) deaths were reported in children below 5 yrs. of age. No deaths were reported in the age group 10 years and above.
 
An overall fever rate of 14.2 percent was observed in the community during the one-month period affecting all age groups and both genders. Maximum attack rate (31.7 percent) was in children below 5 years of age.
 
The cases presented mainly with fever, running nose, cough, and diarrhea. Respiratory distress and convulsions were also present in a few cases, especially in those reporting to hospital. The duration of illness in majority of the cases varied from 2-5 days.
 
The team collected 9 sera and clots. 4 throat swabs and 4 stool samples were also collected. In addition, the team brought 12 sera samples collected on 8 Jun 2003.
 
At NICD laboratories, the samples tested negative for antibodies against measles and herpes. In addition, 4 blood clots were cultured for bacteria and found sterile. High antibody titres were observed against Influenza A & B in most of the patients. However a second sample is required for confirmation. One patient showed the presence of Influenza B antigen in a throat swab. In this sample high antibody titre (1:80) against Influenza B suggest that that the case had infection due to Influenza B virus.
 
The clinico-epidemiological findings show that the present episode of fever consists of respiratory tract infections and affects all age groups with predominance among younger people. The laboratory investigations indicate that the present episode of fever could be due to Influenza B virus. Further tests are in progress to isolate the specific aetiological agents.
 
-- ProMED-mail <promed@promedmail.org>
 
[ProMED-mail just became aware of this official report on the WHO India Representation website today. It should be noted that this report is dated 11-15 Jun 2003, approximately one month ago, and therefore more recent information may be available. The identification of influenza B in one specimen is noted, but the initial descriptions of this outbreak did not seem consistent with influenza (as per the first ProMED-mail posting, "high fever, breathlessness, convulsion, increased salivation, followed by stiffening of jaws within 5-6 hours of the onset of the disease and death".) In the 12 Jun 2003 ProMED-mail posting, a direct report from a physician in West Bengal mentioned "More than 300 have been attacked by the disease, which killed more than 56 persons."
 
The above report suggests that the majority of cases in this outbreak had a respiratory illness that could be classified as influenza-like, and that the observed case fatality rate was approximately 6.3 percent. ProMED-mail would be interested in additional information on further studies of this outbreak, more information on the clinico-epidemiologic investigation, and the results of any toxicologic studies that may have been conducted. - Mod.MPP]
 
Patricia A. Doyle, PhD Please visit my "Emerging Diseases" message board at: http://www.clickitnews.com/ubbthreads/postlist.php?
Cat=&Board=emergingdiseases
 
Zhan le Devlesa tai sastimasa Go with God and in Good Health

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