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AIDS Pioneer Sees Risk
In African Dash For Drugs

By Ben Hirschler
European Pharmaceuticals Correspondent
7-14-3

PARIS (Reuters) -- Two decades into the global AIDS pandemic, governments around the world are finally talking of committing tens of billions of dollars to fight the killer disease in developing countries.
 
But Robert Gallo, the scientist who co-discovered HIV in 1983, warned on Monday there were serious dangers from embarking on widespread treatment in sub-Saharan Africa without adequate medical infrastructure.
 
"Obviously it is critical to get available drugs to developing nations as quickly as possible, but not just to throw this at them," Gallo, director of the U.S.-based Institute of Human Virology, told Reuters.
 
"We've got to have infrastructure created at the same time because we are going to create multi-drug resistant mutants if we don't."
 
Gallo said AIDS patients needed extensive medical care, including testing and monitoring to ensure compliance with drug regimens, something that may simply be impractical in parts of Africa where many do not have basic healthcare.
 
The issue of how to get drugs to the vast majority of the world's 42 million HIV infected people is dominating discussions at the International AIDS Society conference in Paris, where Gallo was speaking.
 
Activists say six million face imminent death without access to affordable drugs and have urged governments to pledge more to the Global Fund to Fight AIDS, Tuberculosis and Malaria in order to speed up treatment in Africa, the center of the pandemic.
 
President Bush in May signed into a law pledging $15 billion to help combat the deadly disease, trebling U.S. spending over five years and sparking calls for other industrialized countries to dig deeper in their pockets.
 
Gallo, however, is something of a dissenting voice in the chorus of support for widespread treatment by highlighting the risk that powerful antiretrovirals, if not taken correctly, can quickly induce virus resistance.
 
"Nobody talks about that...the danger of failure is very real in a few years if the drugs are just dumped there," Gallo said.
 
"There'll be great happiness with the drugs being made available, as I would see the future, for two to five years and then we're going to start seeing problems if it is not done right."
 
Other speakers at the conference acknowledged the need for on-the-ground medical expertise but argued the risk of resistance should not deter the build-up of large treatment programs.
 
© Reuters 2003. All rights reserved.
 
http://www.reuters.com/newsArticle.jhtml?type=scienceNews&storyID=3085993

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