- Hello, Jeff - This is very, very serious. We are now
told that there is a new strain of scrapie, "Nor 98." We just
recently learned of atypical BSE/TSE in cattle which had been identified
in Japan and Italy, and now find out that the SAME phonomena is beginning
to occur in sheep.
-
- PrP genotypes are rarely - actually almost NEVER - identified
in scrapie and associated with mad "animal" disease, have been
seen in cases in Norway since 1998.
-
- Are we finally going to admit that scrapie, TSE, BSE,
CWD, CJD, Kuru et al are all the same disease and have commonality of origin?
Mad cow, or whatever we call it is simply prion disease of "man animal"
disease.
-
- The new mutations are extremely puzzling and very distrubing.
We are NO CLOSER now to understanding or containing mad animal disease
then we were a decade ago. Given the new atypical strains, genotyopes,
we may even be further away then a decade ago.
-
- I do not believe that mad animal is caused solely by
ingesting banned substances, such as bonemeal, in feed. Animals have been
getting approved feed lots for over a decade and yet, the disease progresses
and now even mutates.
-
- The mechinisms of prion mutation and misfolding, in fact
the entire process of pathogenesis of prion disease, is a mystery, and,
in light of this new information, it may be a mystery that science will
not be able to unravel for some time.
-
- Patricia Doyle
-
- From ProMed
-
- Date: 16 Nov 2003
- From: Terry Singletary
- Source: The Veterinary Record, 16 Aug 2003
-
- http://www.ingenta.com/isis/searching/ExpandTOC/ingenta;jsessionid=ftwqleb46v9q?
issue=infobike://bva/vet/2003/00000153/00000007&index=2
-
- [With new information, it appears there is potentially
a new phenotype of 'atypical' BSE/TSE in animals in Japan and France. The
article below indicates a new strain of Scrapie, the 'Nor98', which also
has negative IHC and histology. Although this article does not suggest
a link to the atypical forms seen in cattle, it does seem more than coincidence
that there are also appearing different strains, or perhaps atypical strains
of scrapie as well. It has been believed for years that there is a link
between BSE and scrapie; perhaps this is another bit of research that should
be carefully examined. - Mod.TG]
-
- Cases of scrapie with unusual features in Norway and
designation of a new type, Nor98.
-
- The Veterinary Record, 16 August 2003, vol. 153, no.
7, pp. 202-208(7) Benestad S.L.; Sarradin P.; Thu B.; Schonheit J.; Tranulis
M.A.; Bratberg B.
-
- Abstract: 5 cases of scrapie with unusual features have
been diagnosed in Norway since 1998. The affected sheep showed neurological
signs dominated by ataxia, and had the PrP genotypes homozygous A136 H154
Q171/ A136H154Q171 or heterozygous A136H154Q171/A136R154Q171, which are
rarely associated with scrapie. Brain histopathology revealed neuropil
vacuolisation essentially in the cerebellar and cerebral cortices; vacuolation
was less prominent in the brainstem, and no lesions were observed at the
level of the obex. The deposits of PrPSc were mainly in the cortex of the
cerebellum and cerebrum, and no PrPSc was detectable by immunohistochemistry
or ELISA in the lymphoid tissues investigated.
-
- Western blot analysis showed that the glycotype was different
from other known scrapie strains and from the BSE strain. From a diagnostic
point of view, these features indicate that this type of scrapie, designated
Nor98, could have been overlooked and may be of significance for sampling
in scrapie surveillance programmes.
-
- Document Type: Research article ISSN: 0042-4900
-
- DOI (article): NO_DOI
- SICI (online): 0042-4900(20030816)153:7L.202;1-
- Publisher: BVA Publications
-
- --
- ProMED-mail
- <promed@promedmail.org>
-
- Patricia A. Doyle, PhD
- Please visit my "Emerging Diseases" message
board at: http://www.clickitnews.com/ubbthreads/postlist.php?Cat=&Board=emergingdiseases
- Zhan le Devlesa tai sastimasa
- Go with God and in Good Health
|
