- Hello, Jeff -
-
- It is important to note that both Scarpie and BSE (Mad
Cow Disease) have been found to have typical cases in France. Atypical
BSE has also been found in Japan and Italy.
-
- "This finding suggests either some phenotypic modifications
of PrP(res) following infection by the BSE agent or the existence of alternative
origins of such diseases in cattle."
-
- My guess is that there is the existence of alternative
origins.
-
- Patricia Doyle
-
-
- From ProMED-mail
-
- Office International des Epizooties(OIE), Disease Information
http://www.oie.int/eng/info/hebdo/a_info.htm
-
- Emergency Report
-
- Bovine Spongiform Encephalopathy in France - Atypical
Cases
-
- Translation of information received on 26 Jan 2004 from
Dr Isabelle Chmitelin, Deputy Director General, General Directorate for
Food (DGAL), Ministry of Agriculture, Food, Fisheries and Rural Affairs,
Paris:
-
- Date of the report: 16 Jan 2004.
-
- Date of initial detection of animal health incident:
11 Jan 2004.
-
- Six atypical cases of bovine spongiform encephalopathy
(BSE) have been detected within the framework of the routine active surveillance
programmes (abattoirs, downers).
-
- Affected population: the 6 affected cows were aged from
8 years to 15 years.
-
- Location of the cases: departments of Loire-Atlantique
(2 cases), Cotes-d'Armor (1 case), Creuse (1 case), Loire (1 case) and
Jura (1 case).
-
- Control measures: the cohort of each affected cow was
destroyed in accordance with Regulation No. 999/2001 of the European Parliament
and of the Council of the European Union.
-
- Diagnosis:
-
- In each case, the electrophoretic profiles observed in
the confirmatory tests were different from those observed in classical
bovine spongiform encephalopathy cases (apparent molecular weight of PrPSc
protein, glycoform distribution, detection using P4 monoclonal antibody.
-
- Genetic analysis of several of these atypical cases has
ruled out the hypothesis of a polymorphism in the gene coding for the prion
protein.
-
- Inoculation of samples into laboratory animals is currently
under way to determine more accurately the biological characteristics of
these isolates.
-
- A. Laboratory where confirmatory testing was carried
out: NCTA(1)-Virology Unit, French Agency for Food Safety (AFSSA(2)), Lyon.
-
- B. Confirmatory test used: western blot (RB1 polyclonal
antibody, P4 monoclonal antibody).
-
- (1) NCTA: non-conventional transmissible agents
-
- (2) AFSSA: Agence francaise de securite sanitaire des
aliments
-
- -- ProMED-mail <promed@promedmail.org>
-
- [Atypical BSE in bovines has been recently recorded in
Japan, Italy & France - - see refs. below. - Mod.AS]
-
- References ---------- [1] Japan Yamakawa Y et al. 2003.
Atypical proteinase K-resistant prion protein (PrPres) observed in an apparently
healthy 23-month-old Holstein steer. Jpn. J. Infect. Dis. 56: 221-222.
-
- [2] France Biacabe AG, Laplanche JL, Ryder S, Baron T.
AFSSA-Lyon, Unite 'Virologie- ATNC', 31 Avenue Tony Garnier, 69364 Lyon
Cedex 07, France. Distinct molecular phenotypes in bovine prion diseases.
EMBO Rep. 2004 Jan;5(1):110-115
-
- Bovine spongiform encephalopathy (BSE) in cattle, the
most likely cause of variant Creutzfeldt-Jakob disease in humans, is thought
to be caused by a unique infectious agent, with stable features, even when
transmitted to other species. Here, we show the existence of an atypical
molecular phenotype among cattle diagnosed with BSE in France. Following
western blot analysis, three cases showed unusual features of the electrophoretic
profiles of the protease-resistant prion protein (PrP(res)) accumulating
in the brain. The PrP(res) patterns were similar in these three atypical
cases, showing a higher molecular mass of unglycosylated PrP(res) and strong
labelling by P4 monoclonal antibody compared to 55 typical BSE cases. This
finding suggests either some phenotypic modifications of PrP(res) following
infection by the BSE agent or the existence of alternative origins of such
diseases in cattle.
-
- SCRAPIE, ATYPICAL, SHEEP - FRANCE: OIE **************************************
Date: 31 Jan 2004 From: ProMED-mail <promed@promedmail.org> Source:
Office International des Epizooties (OIE), Disease Information
-
- http://www.oie.int/eng/info/hebdo/a_info.htm
-
-
- Emergency Report
-
- Scrapie In France - Atypical Cases
-
- Translation of information received on 26 Jan 2004 from
Dr Isabelle Chmitelin, Deputy Director General, General Directorate for
Food (DGAL), Ministry of Agriculture, Food, Fisheries and Rural Affairs,
Paris:
-
- Date of the report: 16 Jan 2004.
-
- Date of initial detection of animal health incident:
12 Mar 2003 [10 months ago - Mod.JW].
-
- 3 atypical cases of scrapie have been detected in ewes
aged from 5 years to 17 years. Genotyping of the animals for the gene coding
for the prion protein has shown that these animals are homozygous for the
allele ARR, associated with the highest resistance to the development of
clinical signs of scrapie.
-
- Location of the cases: departments of Haute-Vienne (2
cases) and Ain (1 case).
-
- Diagnosis: the cases were detected within the framework
of the routine active surveillance programmes (abattoirs, downers) implemented
in accordance with Regulation No. 999/2001 of the European Parliament and
of the Council of the European Union.
-
- A. Laboratory where confirmatory testing was carried
out: NCTA(1) Virology Unit of the French Agency for Food Safety (AFSSA(2)),
Lyon.
-
- B. Diagnostic tests used: ELISA(3) and immunohistochemical
tests. Inoculation of samples into laboratory animals is currently under
way to determine more accurately the biological characteristics of these
isolates.
-
- (1) NCTA: non-conventional transmissible agents (2) AFSSA:
Agence francaise de securite sanitaire des aliments (3) ELISA: enzyme-linked
immunosorbent assay -- ProMED-mail <promed@promedmail.org>
-
- {The following comment is adapted from the 2003 ProMED
reference below.] [With new information, it appears there is potentially
a new phenotype of 'atypical' BSE/TSE in animals in Japan and France. The
article below indicates a new strain of Scrapie from Norway, the 'Nor98',
which also has negative IHC and histology. Although this article does
not suggest a link to the atypical forms seen in cattle, it does seem more
than coincidence that there are also appearing different strains, or perhaps
atypical strains of scrapie as well. It has been believed for years that
there is a link between BSE and scrapie; perhaps this is another bit of
research that should be carefully examined. -
-
- Ref: Cases of scrapie with unusual features in Norway
and designation of a new type, Nor98. Benestad S.L.; Sarradin P.; Thu B.;
Schonheit J.; Tranulis M.A.; Bratberg B. The Veterinary Record, 16 August
2003, vol. 153, no. 7, pp. 202- 208(7) - Mod.TG]
-
- Patricia A. Doyle, PhD Please visit my "Emerging
Diseases" message board at: http://www.clickitnews.com/ubbthreads/postlist.php?Cat=&Board=emergingdiseases
Zhan le Devlesa tai sastimasa Go with God and in Good Health
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