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Genetics May Explain
West Nile's Rapid Spread

By Marina Jimenez
The Globe and Mail
3-6-4



An international team of scientists analyzing mosquitoes from five continents has published a study that appears to solve the mystery of why West Nile virus spread so rapidly in North America but not in Europe.
 
The mosquitoes that transmit the potentially fatal virus in North America are hybrids of two strains of Culex pipiens that like to feast on the blood of both birds and humans, thus facilitating the spread of the disease from one species to another, according to the study, Why West Nile is West of the Atlantic, published today in the journal Science.
 
In Europe, the Culex pipiens species normally bites either birds or mammals, but not both, which explains why the West Nile outbreaks there have been relatively small.
 
"It was an exciting discovery," said Dina Fonseca, of the Smithsonian Institution's Museum of Natural History in Washington, who led the study.
 
"There are an enormous number of hybrid mosquitoes in the U.S. and we think they are the main vectors of the disease here."
 
West Nile virus, which attacks birds and is transmitted to humans by mosquitoes that eat the blood of humans and birds, surfaced in New York City in 1999.
 
Ms. Fonseca and several scientists in Europe and Japan examined mosquito samples from 33 sites in Germany, Britain, Australia, Italy, Japan, Jordan and the United States.
 
In the United States, more than 40 per cent of the Culex pipiens mosquitoes were hybrids. In Southern Europe, no more than 10 per cent of the mosquitoes were hybrids, while almost none from Northern Europe were.
 
Andrew Spielman, entomologist at the Harvard School of Public Health in Boston, does not agree with the conclusions of the study. He believes West Nile virus spread so rapidly in North America because it is relatively new on the continent and birds have not built up an immunity to it.
 
"They have never seen the virus before and that's why the intensity of transmission is so great now in U.S. and in Canada," he said.
 
Mark Loeb, a Canadian West Nile researcher, said the study does not explain where the next outbreak of the disease will occur, or why it shifted from the east to the western U.S. states and prairie provinces.
 
"As well, the disease on the prairies this summer was transmitted by another kind of mosquito, the Culex tarsalis," said the associate professor at McMaster University
 
West Nile in the United States has been isolated in 38 different mosquito species.
 
© 2004 Bell Globemedia Publishing Inc. All Rights Reserved.
 
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