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West Nile 'Causes Lasting Damage'
BBC News
8-22-4
 
Being infected with severe West Nile Virus can cause long-term health problems, a study has found.
 
Experts from the New York Academy of Medicine followed 42 adults who had been admitted to hospital with the disease following an outbreak in 1999.
 
They found two thirds of them still had mental or physical health problems a year later.
 
The research, published in the journal Emerging Infectious Diseases, found the elderly were worst affected.
 
It is the first time people infected with the mosquito-borne disease have been followed for so long.
 
West Nile Virus is generally seen as causing mild symptoms such as fever or skin rashes. But the severe form of the disease can cause encephalitis and meningitis, and can even prove deadly.
 
The virus killed 264 in the US last year.
 
Last month, two cases were confirmed in Ireland. Both patients had recently returned from the Algarve in Portugal.
 
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In the study, patients were interviewed by phone at six, 12 and 18 months after falling ill.
 
After 12 months, 63% of those questioned were still suffering muscle weakness, frequent headaches, difficulty concentrating and other persistent problems.
 
Most of those who recovered were under 65.
 
After 18 months, more than 40% of severely infected patients continued to report difficulty walking, muscle weakness, fatigue and insomnia, while 30% still suffered from memory loss, confusion, depression and irritability.
 
They continued to need assistance with activities of daily living.
 
The research team said their findings, along with evidence from other studies, showed the elderly were most susceptible to the severe form of the virus, and reinforced the need for infection-prevention efforts to focus on that group.
 
Denis Nash, who led the research, said: "Our study showed that many people with severe West Nile virus infection suffered lingering and debilitating symptoms well after they left the hospital,
 
"West Nile virus infection appears to cause longer-term health problems than was previously appreciated."
 
Ian Jones, Professor of Virology at Reading University, told BBC News Online: "The authors claim they have checked for virus presence but show no data to prove the virus is still in these patients at any significant level. Thus, recovery may be the issue rather than viral persistence.
 
"Clinically it is a sound study so the concerns that morbidity is more significant for elderly patients is an important point for patient management, but I don't think it signals the virus as a real persistent infection nor that the effects in the general public at all ages are changing to any great degree. "
 
© BBC MMIV http://news.bbc.co.uk/2/hi/health/3559854.stm




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