- New York, NY (UPI) -- U.S. and Chinese scientists have
discovered that a proposed SARS vaccine triggers an autoimmune response
causing the body to attack itself.
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- Using new tools called glycan microarrays -- which can
examine cell chemistry at extremely small scales -- scientists at Columbia
University in New York and Sun Yat-sen University in China studied a vaccine
made from an inactivated SARS-coronavirus.
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- They found the antibodies the body created to fight the
intentionally weak infection also attacked a particular glycoprotein, a
molecule of linked protein and sugar, that is very common in the human
system.
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- "These observations raise concerns on human use
of the whole virus-based SARS vaccine that is produced by the monkey Vero
E6 cell," the scientists said. The cell line used was produced by
monkey Vero E6 cells.
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- Based on the results, the scientists said it is too risky
at the moment to introduce a whole-viral SARS vaccine to human subjects,
but choosing an alternative cell line or genetically modifying the Vero
E6 cell line might fix the problem.
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