- MADISON -- By comparing influenza
viruses found in birds with those of the avian virus that have also infected
human hosts, researchers have identified key genetic changes required for
pandemic strains of bird flu.
- The new work, reported in the Nov. 16 issue of the journal
Nature, illustrates the genetic changes required for the H5N1 avian influenza
virus to adapt to easily recognize the receptors that are the gateway to
- "We identified two changes that are important,"
says Yoshihiro Kawaoka, the senior author of the Nature paper and a virologist
at the University of Wisconsin-Madison School of Veterinary Medicine. "Both
changes are needed for the H5N1 virus to recognize human receptors."
- The new report provides a molecular blueprint for the
genetic changes required to transform a virus that only infects birds to
a virus capable of easily recognizing human receptors. Receptors are molecules
on the surface of cells that permit the virus to dock with the cell and
commandeer it to initiate a cascade of infection. By knowing what genetic
changes are required for the virus to easily infect human cells, it may
be possible to detect the emergence of pandemic strains earlier, providing
public health officials and vaccine manufacturers with precious time to
prepare for a global outbreak of highly pathogenic influenza. To be successful,
a virus must be able to recognize and attach to a host cell. But human
and avian influenza viruses recognize different cell receptors. Avian flu
viruses have demonstrated an ability to evolve to easily infect humans
by exchanging genes with human viruses that subsequently permit them to
recognize human receptor molecules and gain easy access to cells, typically
in the human respiratory system.
- The change is thought to occur when human patients are
exposed at the same time to a human flu virus and an avian flu virus. Most
viruses, including influenza, readily swap genes with one another.
- In the new study, conducted by an international team
of researchers, the viruses isolated from human patients in Vietnam and
Thailand could recognize both human and avian cell receptors. By contrast,
the viruses found in chickens and ducks could only recognize the receptors
on avian cells.
- The work helps flesh out the changes that have occurred
in the worrisome strain of avian influenza virus known as H5N1, a strain
some fear could be the organism that will trigger a pandemic of virulent
human influenza. The avian virus has already changed dramatically from
when it was first identified in 1997, says Kawaoka, who also holds an appointment
at the University of Tokyo.
- "There are big differences between the virus first
found in 1997 and the virus we see now," Kawaoka explains. "We
are watching this virus turn itself into a human pathogen."
- The mutations found by Kawaoka's group have not yet conferred
a complete ability on avian flu to easily recognize the topography of human
cells, but they are key steps on that pathway. More mutations, says Kawaoka,
will be required for the virus to fully adapt to humans, but it is not
known how many mutations are needed for such a change.
- However, if scientists are able to continue to monitor
and secure viral isolates from humans infected with bird flu, they may
be able to map a mutation trajectory that will help predict when the avian
virus will cross the threshold to become a human pathogen.
- The last two flu pandemics in 1957 and 1968 were caused
by avian viruses that had accumulated enough genetic mutations to be considered
hybrids of animal and human viruses, Kawaoka notes.
- Patricia A. Doyle DVM, PhD
- Bus Admin, Tropical Agricultural Economics
- Univ of West Indies
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