- Subject: Cross-sequence transmission of sporadic Creutzfeldt-Jakob
disease creates a new prion strain
-
- Date: August 25, 2007
-
- snip...
-
- In this study, the strain-dependent traits of sCJDMM1
prions were inherited through cross-sequence transmission without any
modification. The humanized mice with 129V/ V produced type 1 PrPres after
inoculation with sCJD-MM1 prions. Because sCJD-VV1 cases are extremely
rare (at most 1-2% of the total number of sCJD cases) and characterized
by early onset (mean age at onset: 39.3 years) (5),
-
- ####################################
-
- our results raise the possibility that CJD cases classified
as VV1 may include cases caused by iatrogenic transmission of sCJD-MM1
prions or food-borne infection by type 1 prions from animals, e.g., chronic
wasting disease prions in cervid. In fact, two CJD- VV1 patients who hunted
deer or consumed venison have been reported (40, 41). The results of the
present study emphasize the need for traceback studies and careful re-examination
of the biochemical properties of sCJD-VV1 prions.
-
- ###################################
-
- In conclusion, cross-sequence transmission of sCJD-VV2
prions generates a new prion strain with altered conformational properties
and disease phenotypes as p-dCJD prions. Furthermore, the newly generated
prions have unique transmissibility including the traceback phenomenon.
In the future, if atypical prion strains emerge through cross-sequence
transmission, especially from animals, traceback studies will enable us
to identify the origin of the prions.
-
- REFERENCES...snip...end
-
- FULL TEXT
-
- http://www.jbc.org/cgi/content/abstract/M704597200v1?
maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=Cross-sequence
+transmission+of+sporadic+Creutzfel
- dt-Jakob+disease+creates+a+new +&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT
-
-
- Colorado Surveillance Program For Chronic Wasting Disease
- Transmission to Humans (TWO SUSPECT CASES)
- http://lists.ifas.ufl.edu/cgi-bin/wa.exe?A2=ind0704&L=sanet-
mg&T=0&P=1165
-
- FULL TEXT
- http://lists.ifas.ufl.edu/cgi-bin/wa.exe?A2=ind0708&L=sanet-
mg&T=0&P=21267
-
-
- CWD Experts Address First Meeting Of Advisory Committee
- http://www.biggamehunt.net/forums/viewtopic.php?t=13925
-
- PART 2
- http://www.biggamehunt.net/forums/viewtopic.php?p=62733#62733
-
-
- From: Terry S. Singeltary Sr. <flounder9@VERIZON.NET>
- Sent: Tuesday, August 21, 2007
- Subject: TWO MORE Nor98 atypical Scrapie cases detected
in USA bringing
- total to 3 cases to date
-
- Infected And Source Flocks
-
- As of June 30, 2007, there were .....
-
- snip...
-
- One field case and one validation case were consistent
with Nor-98 scrapie.
-
- http://www.aphis.usda.gov/animal_health/animal_diseases/scrapie/
downloads/monthly_scrapie_rpt.pps
-
-
- IN the February 2007 Scrapie report it only mentions
;
-
- ''One case was consistent with Nor98 scrapie.''
-
- http://www.aphis.usda.gov/animal_health/animal_diseases/scrapie/
-
- (please note flocks of origin were in WY, CO, AND CA.
PERSONAL COMMUNCATIONS
- USDA, APHIS, VS ET AL. ...TSS)
-
-
- NOR98 SHOWS MOLECULAR FEATURES REMINISCENT OF GSS
- http://lists.ifas.ufl.edu/cgi-bin/wa.exe?A2=ind0708&L=sanet-
mg&T=0&P=14553
-
- An evaluation of scrapie surveillance in the United States
- http://lists.ifas.ufl.edu/cgi-bin/wa.exe?A2=ind0708&L=sanet-
mg&T=0&P=3427
-
-
- FOIA REQUEST FOR ATYPICAL TSE INFORMATION ON VERMONT
SHEEP
- http://lists.ifas.ufl.edu/cgi-bin/wa.exe?A2=ind0708&L=sanet-
mg&T=0&P=10451
-
-
- SEAC New Forms Of Bovine Spongiform Encephalopathy
- 1 August 2007
- From: Terry S. Singeltary Sr.
- Date: Sun, 5 Aug 2007 13:09:38 -0500
-
- http://lists.ifas.ufl.edu/cgi-bin/wa.exe?A2=ind0708&L=sanet-
mg&T=0&P=3573
-
-
- POTENTIAL MAD CAT ESCAPES LAB IN USA
- http://lists.ifas.ufl.edu/cgi-bin/wa.exe?A2=ind0708&L=sanet-
mg&T=0&P=7062
-
-
- Terry S. Singeltary Sr.
- P.O. Box 42
- Bacliff, Texas USA 77518
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