If you have a dog... PLEASE read this and send it on. If you don't have a dog, please pass along to friends who do.

This week I had the first case in history of raisin toxicity ever seen at MedVet. My patient was a 56-pound, 5 yr old male neutered lab mix that ate half a canister of raisins sometime between 7:30 AM and 4:30 PM on Tuesday. He started with vomiting, diarrhea and shaking about 1:00 AM on Wednesday but the owner didn't call my emergency service until 7:00 AM .

I had heard somewhere about raisins AND grapes causing acute Renal failure but hadn't seen any formal paper on the subject. We had her bring the dog in immediately. In the meantime, I called the ER service at MedVet, and the doctor there was like me - had heard something about it, but.... Anyway, we contacted the A.S.P.C.A. National Animal Poison Control Center and they said to give IV fluids at 1 1/2 times maintenance and watch the kidney values for the next 48-72 hours.

The dog's BUN (blood urea nitrogen level) was already at 32 (normal less than 27) and creatinine over 5 ( 1.9 is the high end of normal). Both are monitors of kidne y function in the bloodstream. We placed an IV catheter and started the fluids. Rechecked the renal values at < /SPAN> 5 PM and the BUN was over 40 and creatinine over 7 with no urine production after a liter of fluids. At the point I felt the dog was in acute renal failure and sent him on to MedVet for a urinary catheter to monitor urine output overnight as well as overnight care.

He started vomiting again overnight at MedVet and his renal values have continued to increase daily. He produced urine when given Lasix as a diuretic. He was on 3 different anti-vomiting medications and they still couldn't control his vomiting. Today his urine output decreased again, his BUN was over 120, his creatinine was at 10, his phosphorus was very elevated and his blood pressure, which had been staying around 150, skyrocketed to 220.. He continued to vomit and the owners elected to euthanize.

This is a very sad case - great dog, great owners who had no idea raisins could be a toxin. Please alert everyone you know who has a dog of this very serious risk. Poison control said as few as 7 raisins or grapes could be toxic. Many people I know give th eir dogs grapes or raisins as treats including our ex-handler's. Any exposure should give rise to immediate concern.

Even if you don't have a dog, you might have friends who do. This is worth passing on to them.

Confirmation from Snopes about the above...
http://www.snopes.com/critters/crusader/raisins.asp

Why Raisins Can Kill Dogs
Mary Sparrowdancer
12-5-7

According to the USDA's fluoride report, which can be seen here,

http://www.nal.usda.gov/fnic/foodcomp/Data/Fluoride/fluoride.pdf

raisins contain one of the highest amounts of fluoride found in the foods they tested. 

Fluoride is a toxin and it accumulates in the kidneys. As stated in the following paper, fluorine ions in plasma are a "nephrotoxin"- fluoride poisons the kidneys. 
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B8CXB-4M9S196-B&_user=
10&_coverDate=07%2F31%2F2006&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_
acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=018f8d9d6262813c532e591b488b64fe