- Despite the recent discovery of a "new prostate
virus" heralded in the media - a just-released study from Germany,
published in the journal RETROVIROLOGY, claims researchers "found
no traces of the xenotropic murine leukemia virus, or XMRV, in any of the
(589) samples."
-
- Full story at http://www.sciencedaily.com/releases/2009/10/091015191701.htm
-
- Xenotropic Murine Leukemia Virus-Related Virus
-
- May Not Be Associated With Human Prostate Cancer
-
- ScienceDaily -- The xenotropic murine leukemia virus-related
virus (XMRV) which has previously been linked to prostate cancer has been
found to have a dramatically lower prevalence among German prostate cancer
patients, if any. Contrary to some reports, which have found XMRV in 40%
of cases in patients in the US with familial prostate cancer, research
published today in BioMed Central's open access journal, Retrovirology,
has found no link between the two conditions in a large study of German
prostate cancer patients.
-
- The experimental research was undertaken by a team from
the Robert Koch Institute and the Charité in Berlin, Germany, led
by Norbert Bannert and Reinhard Kurth. They used real-time PCR and nested
PCR techniques to genotype the RNase L gene (an interferon regulated antiviral
defence gene) and detect the presence of the XMRV virus in samples collected
from 589 prostate cancer patients between the years 2000 and 2006. Some
samples were also tested for the presence of Env antibodies directed against
XMRV using an ELISA.
-
- Knowledge relating to the genetic susceptibility and
risk factors of prostate cancer increase the likelihood of early detection
and successful treatment of the disease. Previously, the HPC1 locus (hereditary
prostate cancer locus-1) has been identified as a hereditary factor associated
with a predisposition to prostate cancer. The gene RNaseL is found within
this locus. The RNase L gene codes for an endoribonuclease that is involved
in the interferon-regulated antiviral defence pathway. Certain polymophisms
in this gene in which the enzyme product has reduced activity have been
reported by others as being linked to increased risk of prostate cancer
(presumptively due to XMRV-infection) in the US and Japan.
-
- In the current study, from the 589 prostate tumor samples,
76 were found to be homozygous for the previously reported RNase L presumptively
XMRV-susceptible Q (R462Q) genotype, however, neither DNA nor RNA fragments
of XMRV were detected in samples collected from the prostate cancers. ELISA
results show that none of the patients had antibodies directed against
XMRV, suggesting that in German prostate cancer patients at least, there
is no evidence for XMRV infection or XMRV-linked prostate cancer even in
individuals with the RNase L XMRV-susceptible Q genotype. According to
Bannert, "a possible geographical restriction of XMRV and its associations
with cases of prostate cancer should be studied closely", adding that
"the oncogenic potential of the virus must be thoroughly investigated
in order to establish whether or not it can trigger the development of
prostate cancer."
-
- Journal reference
-
- Oliver Hohn, Hans Krause, Pia Barbarotto, Lars Niederstadt,
Nadine Beimforde, Joachim Denner, Kurt Miller, Reinhard Kurth and Norbert
Bannert. Lack of evidence for xenotropic murine leukemia virus-related
virus (XMRV) in German prostate cancer patients.Retrovirology, 2009; (in
press) [link]
- Adapted from materials provided by BioMed Central, via
EurekAlert!, a service of AAAS.
- Email or share this story:
- | More
- Need to cite this story in your essay, paper, or report?
Use one of the following formats:
- APA
-
- MLA
- BioMed Central (2009, October 15). Xenotropic Murine
Leukemia Virus-related Virus May Not Be Associated With Human Prostate
Cancer.ScienceDaily. Retrieved October 17, 2009, from http://www.sciencedaily.com
/releases/2009/10/091015191701.htm
-
-
- Scientist
- Xenotropic Murine Leukemia Virus-related Virus May Not
Be Associated With ...
- Science Daily (press release) - Oct 15, 2009
- ... Reinhard Kurth and Norbert Bannert. Lack of evidence
for xenotropic murine leukemia virus-related virus (XMRV) in German prostate
cancer patients. ...
- Viral link to prostate tumors questioned Los Angeles
Times
- Retrovirus not common in Gemany United Press International
- all 15 news articles »
- Email this story
- Science Briefing
- Los Angeles Times - 14 hours ago
- Researchers led by Drs. Reinhard Kurth and Norbert Bannert
of the Robert Koch Institute in Berlin studied 589 prostate-tumor samples
collected in Germany. ...
-
- Alan Cantwell M.D.
- alancantwell@sbcglobal.net
-
- author of THE CANCER MICROBE
-
- www.ariesrisingpress.com
|
